Sarcoidosis and Monoclonal Gammopathy of Undetermined Significance (MGUS): A True Association or Just a Coincidence?

Table 2

Cases with sarcoidosis and MGUS reported in the literature.

Author	Year, country	Age/sex	Ethnicity/race	First Dx (Sarcoidosis/MGUS)?	Latency	Monoclonal protein type	Progression to MM?	Prognosis/outcome
Antela Lopez [5]	1992, Spain	68 F	UNK	Sarcoidosis	3 YRS	IgM	UNK	Treated with prednisone, diagnosed with NHL 3 YRS later, treated with chemotherapy ⟶ complete remission
Sharma et al. [6]	1992, USA	53 F	AA	Sarcoidosis	17 YRS	IgG	N	Stable 16 YRS later
Sharma et al. [6]	1992, USA	69 F	Caucasian	Diagnosed same time	UNK	IgG	N	UNK
Berner et al [7]	1999, Germany	67 M	UNK	Diagnosed same time. Diagnosed with renal sarcoidosis	UNK	IgG	N	Normalization of kidney function with prednisolone therapy
Sen et al [8]	2002, USA	49 F	AA	Diagnosed same time	UNK	IgG	Y (4 YRS)	Stable 30 MS later
Saad et al. [9]	2009, Israel	67 F	ME/Egyptian	Sarcoidosis	3 YRS	IgG	UNK	UNK
Ghafour and Almakki [10]	2014, USA	69 M	UNK	MGUS. Later diagnosed with renal sarcoidosis	1 YRS	IgG	N	UNK
Guboutan et al. [11]	2016, USA	57 F	Caucasian	MGUS	4 YRS	UNK	N	Treated with steroid taper for 4 MS. Resolution of symptoms 2 YRS later
Abdulai and Englert [12]	2016, USA	58 M	Caucasian	MGUS. Later diagnosed with neurosarcoidosis	2 MS	IgG	N	UNK
Armaral et al. [13]	2017, Brazil	54 F	UNK	Diagnosed same time	UNK	IgG	N	UNK

Abbreviations: M: male; F: female; AA: African American; ME: Middle Eastern; UNK: unknown; not mentioned. Y: yes; N: no; YRS: years; MS: months; NHL: non-Hodgkin’s lymphoma. MGUS: Monoclonal gammopathy of undetermined significance.