Two Cases of γ-Heavy Chain Disease and a Review of the Literature

Figure 7

Bone marrow stain of Case 2. (a) CD138 highlights plasma cells—here admixed with lymphocytes (which are CD138 negative). Note also granular golden-brown haemosiderin deposits. (b) CD56—some plasma cells are positive; this is an interesting finding, as plasma cells of lymphoplasmacytic lymphoma usually do not express this marker. It indirectly suggests that the “other clone” may be more of plasma cell myeloma-like (myeloma-like MGUS). Haemosiderin which is naturally yellow/brown is present as well.

(a)

(b)