Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall

<div>Case 1: FISH studies for <i>IgH</i>-<i>CCND1</i> fusion were negative (a). This assay was repeated in a reference lab and was again negative. PCR analysis was performed in the original splenic marginal zone lymphoma (b), and in the relapsed lymphoma (lymph node, and clonal PCR amplification products (c) were compared. Amplification products of the same size in base pairs in the initial and relapsed lymphomas were present, supporting that the tumors were clonally related.</div>

Case Reports in Hematology

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Figure 3: Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall 

Figure 3 | Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall 