Chronic Myelomonocytic Leukemia following Multicentric Castleman Disease

Figure 1

(a) and (b) HRCT of the chest at diagnosis shows bilateral centrilobular nodules, thickening of the interlobular septa, and mediastinal lymphadenopathy. (c) and (d) Histological findings of the pulmonary nodule show infiltration of polyclonal plasma cells around the bronchovascular bundles and in the interfollicular areas of the nodes (H&E, 50x and 200x). (e) and (f) Sheets of mature plasma cells are present within the interfollicular region and are highlighted by positive immunostaining of IgG- and IgG4-negative plasma cells (immunohistochemistry, 200x).

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