Case Report
Anti-CD20 Treatment of Autoimmune Hemolytic Anemia Refractory to Corticosteroids and Azathioprine: A Pediatric Case Report and Mini Review
Table 1
Hematological parameters and treatment during the course of the disease.
| | Admission | 4th day | 4th week | 3rd month | 6th month | 7th month | 9th month | 13th month | 15th month | 3rd year |
| Agent | Methylprednisolone (3 mg/kg/day) | Prednisolone (2 mg/kg/day) | Prednisolone (2 mg/kg/day) | Prednisolone (1 mg/kg/day) | — | Prednisolone (2 mg/kg/day) | Prednisolone (2 mg/kg/day) | — | — | — | Transfusion | | | | | | Azathioprine (2 mg/kg/day) | Azathioprine (3 mg/kg/day) | — | — | | | | | | | | | Rituximab | | | Hb | 5.1 | 9.2 | 11.5 | 12.3 | 12.8 | 7.3 | 11.6 | 9.8 | 12.9 | 13.2 | Rets | 220 | 120 | 92 | 79 | 75 | 186 | 95 | 115 | 83 | 62 | DAT | +++ IgG | +++ IgG | +++ IgG | +++ IgG | +++ IgG | +++ IgG | +++ IgG | +++ IgG | +++ IgG | Negative | LDH | 1540 | 720 | 523 | 310 | 285 | 1230 | 310 | 370 | 290 | 250 | TBL | 3.8 | 1.9 | 1.2 | 0.9 | 0.9 | 2.9 | 1.0 | 1.2 | 0.9 | 0.8 |
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Hb (g/dl): hemoglobin; Rets (x 103/μL): reticulocytes; DAT: direct antiglobulin test; LDH (U/L): lactate dehydrogenase; TBL (mg/dl): total bilirubin.
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