Case Reports in Hematology / 2018 / Article / Tab 1

Case Report

Fusarium Endophthalmitis, Unusual and Challenging Infection in an Acute Leukemia Patient

Table 1

Follow-up and course of the disease.

TimeDiagnosis+1 month+3 months+4 months+5 months+6 months

EventAMLRefractory AMLRefractory AML, probable fungal infection with thorax CTRefractory AML blurred vision with the right eye—infiltration in the thalamus and right eyeRefractory AML enucleation and debridement of the right eyeAllogeneic stem cell transplant from HLA-matched sibling

TreatmentPosaconazole 200 mg (5 mL) PO TID remission induction 7 + 3 (cytarabine + idarubicin)Posaconazole 200 mg (5 mL) PO TID remission induction FLAG-IDA (fludarabine-cytarabine-idarubicin)Voriconazole 6 mg/kg IV q12 hr for first 24 hours, then 4 mg/kg IV q12 hr bridging therapy for allogeneic stem cell transplantation (clofarabine-cytarabine)Voriconazole 4 mg/kg IV q12 hr + liposomal amphotericin B 5 mg/kg IV qdayVoriconazole 4 mg/kg IV q12 hr + liposomal amphotericin B 5 mg/kg IV qdayDied + 21 day of transplantation due to pneumosepsis