Case Reports in Hematology / 2018 / Article / Fig 2

Case Report

A Rare Case of Systemic AL Amyloidosis with Muscle Involvement: A Misleading Diagnosis

Figure 2

Presence of amyloid fibrils confirmed by electron microscopy. Muscle biopsy was routinely fixed in 2.5% glutaraldehyde in cacodylate buffer, postfixed in osmium tetroxide, and dehydrated and embedded in Araldite; thin sections were studied under Philips CM100 TEM fibrillary structures likely resembling amyloid fibrils in the perimysial pericapillary area (a) (bar = 0.1 µm); an endomysial capillary lumen with a lightly thicker wall without amyloid fibrils (b) (bar = 0.2 µm). Postembedding immunostaining with a polyclonal anti-kappa light chain antibody (Dako, 1 : 100) thin section was studied under a Jeol JEM-1400 Plus electron microscope (c).
(a)
(b)
(c)

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.