Case Reports in Hematology / 2019 / Article / Tab 1

Case Report

Aplastic Anemia and Good Syndrome in a Heavily Treated Stage IV Thymoma Patient: A Case Report and Review of the Literature

Table 1

All reported cases of concomitant Good syndrome and aplastic anemia. The table is divided into seven horizontal rows illustrating reported cases including ours and twelve vertical columns illustrating literature, patient age and sex, disease progression, year of presentation of AA in relation to the diagnosis of thymoma, type of thymoma according to available WHO or traditional classification, bone marrow histology, information on serum immunoglobulins and lymphocyte subtypes, related manifestations, information on treatment received for thymoma, treatment for AA, and outcome and cause of death.

ReportAge (years) sexDisease progressionAplastic anemia and diagnosis of thymomaThymoma histology and stageBone marrowGammaglobulin and lymphocytesRelated featuresTherapy for thymomaTherapy for AAOutcomeCause of death

Chapin [16]67 MPRCA1, GS2, aplastic anemia10 years after the onset of thymomaSpindle cell thymomaAplasia with lymphoid infiltrateHypogammaNaNoneSteroidsDeathHemorrhage
Korn et al. [17]75 MGS2+ agenerative anemia, pancytopenia7 years after the onset of thymomaMixed thymoma with plasmacytoid cells locally invasiveAplasia + aggregates of mature lymphocytesHypogamma and severe impairment of cell immunityAnti-AchR+Surgery and nitrogen mustard instillation after the onset of anemiaSteroids and hormonesDeathPulmonary embolus
Rogers et al. [14]60 FGS2+ aplastic anemiaSimultaneousSpindle cell encapsulated thymomaMarked hyopoplasia + few lymphocytes and plasma cellsHypogammaAna+Surgery after the onset of anemiaSteroids and hormonesDeathPneumonia and sepsis
Burrows and Carroll [15]90 MGS2+ aplastic anemiaSimultaneousSpindle cell locally invasiveMarked hypoplasia + aggregates mature lymphocytesSlightly hypogammaNoneNoneSteroidsDeathSepsis
Mir et al. [18]68 MGS2+ aplastic anemiaSimultaneousNaHypoplasiaHypogamma and lymphopeniaNaNoneNaDeathNa
Kristiansen et al. [19]61 MGS2, pancytopenia3 years after the onset of thymomaNaHypoplasia + T lymphocytosisHypogamma CD4/CD8 invertedNoneSurgery before the onset of aplastic anemiaATGα, steroids, CSAβ, CTXγ, ivIGδ, G-CSFε, eltrombopagResponse to eltrombopag + G-CSF#
Our case53 MGS2,, PRCA1, AATP3, aplastic anemia34 years after the onset of thymomaThymoma B2-B3 IV stageAplasia with modest lymphoid infiltrateHypogamma CD4/CD8 inverted absent B lymphocytesAnti-AchR+Surgery radiation and chemotherapy before the onset of aplastic anemiaSteroids, ivIGδ, G CSFε, eltrombopagDeathSepsis

Na: not available; 1 PRCA: pure red cell aplasia; 2 GS: Good syndrome; 3 AATP: amegakaryocytic thrombocytopenia; Ana+: antinuclear antibodies positive; AchR+: acetylcholine receptor antibodies positive; αATG: antithymocyte globulin; βCSA: cyclosporine; γCTX: cyclophosphamide; δivIG: intravenous gammaglobulin; εG-CSF: granulocyte colony-stimulating factor.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.