Case Report

Hemophagocytic Syndrome-Associated Variant of Methotrexate-Associated Intravascular Large B-Cell Lymphoma in a Rheumatoid Arthritis Patient

Table 1

Summary of the patient’s initial laboratory data.

White blood cells3750/μL
 Monocyte15.5%
 Lymphocyte10.0%
 Basophil0.0%
 Eosinophil0.0%
 Segmented51.0%
 Band20.0%
 Metamyelocyte0.5%
 Myelocyte0.5%
 Atypical lymphocyte2.5%
Red blood cells299 × 104/μL
Hemoglobin9.4 g/dL
MCV90.6 fL
Reticulocytes6.94 × 104/μL
Platelets5.0 × 104/μL
TP5.1 g/dL
Albumin2.6 g/dL
LDH1336 IU/L
AST83 IU/L
ALT23 IU/L
ALP385 IU/L
γ-GTP80 IU/L
TB1.3 mg/dL
DB0.3 mg/dL
BUN22 mg/dL
Creatinine0.8 mg/dL
CRP8.2 mg/dL
Fe101 μg/dL
Ferritin5854.7 ng/mL
sIL-2R12600 U/mL
PT84%
PT-INR1.09
aPTT33.2 sec
D-dimer2.8 μg/mL

Segmented, segmented neutrophil. Band, band neutrophil. MCV, mean corpuscular volume. TP, total protein. LDH, lactate dehydrogenase. AST, aspartate transaminase. ALT, alanine aminotransferase. ALP, alkaline phosphatase. γ-GTP, γ-glutamyltransferase. TB, total bilirubin. DB, direct bilirubin. BUN, blood urea nitrogen. CRP, C-reactive protein. Fe, iron. sIL-2R, soluble interleukin-2 receptor. PT, prothrombin time. PT-INR, the international normalized ratio of prothrombin time. aPTT, activated partial thromboplastin time.