PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia

Table 2

Quantitative RT-PCR analysis of fusion transcripts in peripheral blood over time.

Months after CML diagnosis	p210 BCR-ABL1 (IS%)	PML-RARA (bcr3 F/C ratio)	WBC (×10^3/μL)
0	93.869	0	44
1	49.315	ND	3.7
2	15.427	ND	2.6
3	1.085	ND	1.9
5	2.678	ND	2.3
6	1.594	ND	2.6
8	0.691	0	3.7
9	0.567	0.0003	3.2
12	0.879	0.0057	2.3
14	1.174	0.0031	2.7
17	45.328	0.2029	1.7
19	0.107	0	2.5
21	0.138	0	3.8
24	0.070	0	2.9
27	0.074	0	3.5
30	0.104	0	4.1
33	0.045	0	4.2
36	0.081	0	4.8

Blast crisis diagnosis. CML, chronic myeloid leukemia; IS%, international scale percent ratio; F/C, fusion to control; WBC, white blood count; ND, not done.