Case Reports in Hematology / 2020 / Article / Tab 1

Case Report

A Rare Case of Coexisting Breast Cancer and Refractory Acute Myeloid Leukemia

Table 1

Cases of synchronous occurrence of BC and AML in the literature.

CaseLatencyMorphologyPhenotypeKaryotypeGeneticsOutcome

Jacobs and Carey [3]SimultaneousNANANANANA
Carey [3]SimultaneousNANANANADied during induction (no autopsy).
Rosner et al. (case 18) [4]3 monthsNANANANADied in CR of AML for diabetic coma and gastrointestinal hemorrhage.
Ershler (case 6 and 8) [5]6 monthsNANA45, banding not possibleNARD. Died in 3 months.
SimultaneousM4NANANADied during induction in 9 days.
Mishra et al. [2]<1 monthM1CD13+, CD33+, HLA−DR+, CD7+46, XXp53 mutation in both AML and BCDied from septicemia, DIC, and intracerebral bleeding after reaching a CR.
Hu et al. [6]SimultaneousM4HLA-DR+, CD117+, CD34+, CD33+, CD64+, CD11c+, CD13+, CD38+47, XX, +11NPM1 and CEBPA mutationsRD. Alive in CR after 3 lines of chemotherapy. stable BC.
Present case6 monthsCD34+, CD117+, CD133+, HLA-DR+, CD4+, CD7+, CD13+, TdT+, CD33+/−46, XXNegativeRD. Alive in CR of AML after allogeneic HSCT. CR of BC.
Our case, data not publishedSimultaneousM2CD34+/−, CD117+, HLA−DR+, CD13+, CD33+, CD7+46, XXMLL self-fusionRD. Died of AML in 13 months.

AML: acute myeloid leukemia; RD: refractory disease; CR: complete remission; NA: not available; BC: breast cancer.

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