Aggressive CD5-Positive Primary Bone Marrow Diffuse Large B-Cell Lymphoma with Leukemic Presentation

Figure 1

The patient’s peripheral blood features medium and large-sized cells with scant cytoplasm and irregular nuclear contours (a; 400x magnification). Approximately 70–80% of the cellular elements within his hypercellular bone marrow biopsy show morphologic characteristics similar to those seen in the peripheral blood (b; 400x magnification). The cells are positive for CD20 (c), CD10 (d), and CD5 (e) by immunohistochemistry (400x magnification). Ki-67 demonstrates a high proliferation index of 80% (f; 400x magnification).