Sézary Syndrome with CD4/CD8 Double-Negative Neoplastic T Cells in Peripheral Blood

Figure 3

Hematoxylin-eosin (HE) staining and immunohistochemical staining of skin biopsy specimens (×200). HE staining shows the infiltration of abnormal lymphocytes in the superficial dermis (upper left). Immunohistochemical staining shows abnormal lymphocytes are positive for CD3 (upper middle) and CD4 (upper right), but negative for CD7 (lower left), CD8 (lower middle), and CD30 (lower right).