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Case Reports in Hepatology
Volume 2013 (2013), Article ID 101862, 4 pages
Case Report

Combined Hepatocellular Carcinoma and Fibrolamellar Carcinoma Presenting as Two Adjacent Separate Lesions in a Young Boy: First Case Report from Asia

Department of Pathology, Christian Medical College, Vellore, Tamil Nadu 632004, India

Received 25 January 2013; Accepted 13 February 2013

Academic Editors: A. Grasso, F. Imazeki, G. H. Koek, H. Komatsu, H. H. Lin, Z.-Y. Lin, and F. Pérez Roldán

Copyright © 2013 Pradyumn Singh and Banumathi Ramakrishna. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. T. Bosman, WHO Classification of Tumours of the Digestive System, World Health Organization, and International Agency for Research on Cancer, Lyon, France, 4th edition, 2010.
  2. K. Okada, Y. I. Kim, K. Nakashima et al., “Fibrolamellar hepatocellular carcinoma coexistent with a hepatocellular carcinoma of common type: report of a case,” Surgery Today, vol. 23, no. 7, pp. 626–631, 1993. View at Google Scholar · View at Scopus
  3. A. Hasegawa, “Fibrolamellar hepatocellular carcinoma: a case report of a resected case with an electron microscopic and flow cytometric analysis,” Pathology International, vol. 46, no. 1, pp. 84–90, 1996. View at Google Scholar · View at Scopus
  4. A. Okano, K. Hajiro, H. Takakuwa, and Y. Kobashi, “Fibrolamellar carcinoma of the liver with a mixture of ordinary hepatocellular carcinoma: a case report,” American Journal of Gastroenterology, vol. 93, no. 7, pp. 1144–1145, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Seitz, A. Zimmermann, H. Friess, and M. W. Buchler, “Adult-type hepatocellular carcinoma in the center of a fibrolamellar hepatocellular carcinoma,” Human Pathology, vol. 33, no. 7, pp. 765–769, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. K. G. Ishak, Z. D. Goodman, and J. T. Stocker, Tumours of the Liver and Intrahepatic Bile Ducts, Atlas of Tumor Pathology, 3rd Series, Fascicle 31, Armed Forces Institute of Pathology, Washington, DC, USA, 2001.
  7. S. C. Ward, J. Huang, S. K. Tickoo, S. N. Thung, M. Ladanyi, and D. S. Klimstra, “Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation,” Modern Pathology, vol. 23, no. 9, pp. 1180–1190, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Yamamoto, K. Watanabe, M. Nagata et al., “Transformation of fibrolamellar carcinoma to common hepatocellular carcinoma in the recurrent lesions of the rectum and the residual liver: a case report,” Japanese Journal of Clinical Oncology, vol. 29, no. 9, pp. 445–447, 1999. View at Google Scholar · View at Scopus
  9. Y. C. Chang, Y. C. Dai, and N. H. Chow, “Fibrolamellar hepatocellular carcinoma with a recurrence of classic hepatocellular carcinoma: a case report and review of oriental cases,” Hepato-Gastroenterology, vol. 50, no. 53, pp. 1637–1640, 2003. View at Google Scholar · View at Scopus
  10. H. M. Ross, H. D. J. Daniel, P. Vivekanandan et al., “Fibrolamellar carcinomas are positive for CD68,” Modern Pathology, vol. 24, no. 3, pp. 390–395, 2011. View at Google Scholar
  11. M. Torbenson, “Fibrolamellar Carcinoma: 2012 Update,” Scientifica, vol. 2012, Article ID 743790, 15 pages, 2012. View at Publisher · View at Google Scholar
  12. P. Vivekanandan, M. Torbenson, and B. Ramakrishna, “Hepatitis B virus-associated hepatocellular carcinoma from India: role of viral genotype and mutations in CTNNB1 (beta-catenin) and TP53 genes,” Journal of Gastrointestinal Cancer, vol. 42, no. 1, pp. 20–25, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. J. R. Craig, R. L. Peters, H. A. Edmondson, and M. Omata, “Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinico-pathologic features,” Cancer, vol. 46, no. 2, pp. 372–379, 1980. View at Google Scholar · View at Scopus
  14. A. Durnez, C. Verslype, F. Nevens et al., “The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell origin,” Histopathology, vol. 49, no. 2, pp. 138–151, 2006. View at Publisher · View at Google Scholar · View at Scopus