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Case Reports in Hepatology
Volume 2017, Article ID 3180984, 5 pages
Case Report

Herpes Simplex Virus Hepatitis: A Presentation of Multi-Institutional Cases to Promote Early Diagnosis and Management of the Disease

1Department of Internal Medicine, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH 44106, USA
2Department of Transplant Surgery, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, USA
3Department of Internal Medicine, Louis Stokes VA Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA

Correspondence should be addressed to Ashwinee Natu; moc.liamg@utan.eeniwhsa

Received 19 March 2017; Accepted 2 July 2017; Published 1 August 2017

Academic Editor: Melanie Deutsch

Copyright © 2017 Ashwinee Natu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To compare three cases of Herpes simplex virus (HSV) hepatitis to increase early diagnosis of the disease. Case1. A 23-year-old man with Crohn’s disease and oral HSV. HSV hepatitis was diagnosed clinically and he improved with acyclovir. Case2. An 18-year-old G1P0 woman with transaminitis. Despite early empiric acyclovir therapy, she died due to fulminant liver failure. Case3. A 65-year-old woman who developed transaminitis after liver transplant. Diagnosis was confirmed by biopsy and she had resolution of acute liver failure with acyclovir. Conclusion. It is imperative that clinicians be aware of patients at high risk for developing HSV hepatitis to increase timely diagnosis and prevent morbidity and fatality.