Case Reports in Hepatology / 2018 / Article / Tab 2

Case Report

Fatal Invasive Cryptococcal Infection in an HIV-Negative Elderly Patient with Decompensated Hepatic Cirrhosis

Table 2

Cirrhosis-related cryptococcosis; Japanese experiences.

ReferenceAge/GenderCauses of liver cirrhosisSymptomsCryptococcal 
infection
TreatmentOutcome 
(survival)

1Nakamura 201668/FPBCfeverperitonitis 
fungemia
MCFGDied 
(32 days)
2Haga 201559/MHCVdyspnea 
PE
pulmonary, 
MRSA
surgeryDied 
(8 days)
3Hokari 201058/FPBCdiarrheasystemicVCMDied 
(16 days)
4Akiyama 201064/MAlcoholseizuremeningitisAMPH-B 
F-FLCZ
Died 
(23 days)
5Mitomi 200443/MAlcoholheadache 
fever, 
general malaise
meningitisFLCZ 
AMPH-B
Died 
(57 days)
6Touge 199960/MHBVheadache 
nausea
meningitisFLCZAlive
7Arata 199658/MNAfever 
cavernous lung mass
pulmonary/ 
meningitis
FLCZAlive 
(22 days+)
8Miyazaki 199370/MHCVdisturbed consciousnessmeningitisFCLZAlive
9Yoshizawa 199258/MNAfever 
dyspnea
fungemia 
systemic
antibioticsDied
10Okazaki 199043/MNAdisturbed consciousnesssystemicNADied
11Yamamoto 199032/MNAfever 
headache 
hematemesis
meningitis5-FC 
MCZ
Alive
12Present case82/FHBVgeneral malaise 
hypotension 
coma
fungemianoneDied 
(4 days)

Abbreviations. PBC=primary biliary cirrhosis, HBV=hepatitis B virus, HCV=hepatitis C virus, NA=not available, PE=pleural effusion, MRSA= Methicillin-resistant Staphylococcus aureus, MCFG=Micafungin, VCM=Vancomycin, AMPH-B=Amphotericin-B, F-FLCZ= fosfluconazole, FLCZ= fluconazole, 5-FC= flucytosine, MCZ= miconazole.