Case Reports in Hepatology / 2018 / Article / Tab 1

Case Report

Hepatotoxicity Associated with Use of the Weight Loss Supplement Garcinia cambogia: A Case Report and Review of the Literature

Table 1

Summary of patients with Garcinia cambogia related liver injury, characteristics, presentation, pattern of liver injury, and clinical outcome.

Author (year) [ref.]Number Of casesAge Sex Duration of GC containing supplement usePresenting symptomsPattern of liver injuryUpdated RUCAM scoreNumber of cases that underwent liver transplant Mortality

Stevens et al. [10] (2005)228.5M5 weeks; 5 daysFatigue, jaundiceHepatocellular; cholestatic800

Jones and Andrews [11] (2007)119M120 daysNausea, vomiting, and jaundiceHepatocellular700

Laczek and Duncan [12] (2008)324.33M60-90 daysMalaise, jaundice, and pruritus2 hepatocellular; 1 cholestatic800

Dara et al. [13] (2008)236.5F7 days; 14 daysNausea, vomiting, fatigue, anorexia, and abdominal painHepatocellular800

Shim and Saab [14] (2009)128M90 daysFatigue, jaundiceHepatocellular800

Fong et al. [15] (2010)830.96M; 2 F7 to 56 daysNausea, vomiting, fatigue, and itching abdominal painHepatocellular7-8  
NA for 3 patients needing transplant

Danan and Teschke [9] (2010)119M7 daysFever, fatigue, myalgia, arthralgia, and rashCholestatic700

Sharma et al. [16] (2014)127MUnknownNausea, vomiting, abdominal pain, and jaundiceHepatocellular700

Lee et al. [17] (2014)139F2 daysAbdominal pain, anorexia,
nausea, dyspepsia, fatigue, and jaundice

Melendez-Rosado et al. [7] (2015)142F7 daysNausea, abdominal painHepatocellular700

Corey et al. [2] (2016)152F25 daysJaundice, decreased appetite, fatigue, and confusionHepatocellularNA10

Smith et al. [18] (2016)126M7 daysJaundice, fatigueHepatocellularNA10

Lunsford et al. [19] (2016)134M150 daysNausea, vomiting, abdominal pain, and dark urineHepatocellularNA10

Kothadia et al. (present case)126F28 daysFever, nausea, vomiting, abdominal pain, malaise, fatigue, and jaundiceHepatocellular800

Mean age; M: male; F: female; GC: Garcinia cambogia; mean score; NA: not applicable.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.