TY - JOUR A2 - Komatsu, Haruki AU - Suarez, Oscar AU - Perez, María AU - Garzon, Martin AU - Daza, Rodrigo AU - Hernandez, Geovanny AU - Salinas, Carolina AU - Ceballos, Jorge AU - Leon, Enrique P. de AU - Mugnier, Jacqueline AU - Beltrán, Oscar AU - Varón, Adriana PY - 2018 DA - 2018/12/09 TI - Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy SP - 7521986 VL - 2018 AB - Fibrolamellar hepatocarcinoma is an infrequent liver tumor, currently considered to be a variant different from hepatocarcinoma. The differences lie in genomic alterations, a greater prevalence of fibrolamellar hepatocarcinoma in young patients, and its lack of association with underlying liver disease. The clinical presentation is unspecific, with symptoms ranging from abdominal pain, malaise, and weight loss to atypical manifestation which include hyperammonemic encephalopathy. We present the case of a 33-year-old woman with no prior medical history who presented with a coma and a diagnosis of inoperable fibrolamellar hepatocarcinoma requiring a cadaver donor transplant. While she was on the waiting list, she received hemofiltration and ammonium benzoate treatment, with progressive improvement in her state of consciousness. SN - 2090-6587 UR - https://doi.org/10.1155/2018/7521986 DO - 10.1155/2018/7521986 JF - Case Reports in Hepatology PB - Hindawi KW - ER -