Case Reports in Hepatology / 2019 / Article / Fig 1

Case Report

Hepatocellular Adenoma in a Patient with Ornithine Transcarbamylase Deficiency

Figure 1

The explant liver from our patient with OTC deficiency contains a hepatocellular adenoma. (a) The tumor is a well-circumscribed, soft, tan nodule (shown by arrows), measuring 2.0 cm. (b) At low power magnification, the nodule is homogeneous without thick fibrous bands (H&E, 40x). (c) The background liver shows glycogen changes with clear to pink cytoplasm and distinct cell membrane (H&E, 200x). (d) The nodule is composed of hepatocytes with normal N/C ratios (H&E, 100X). (e) Reticulin stain highlights the normal reticulin framework and shows the hepatocellular plates of overall 1–2 cells in thickness (200x). (f) Immunostaining for HepPar1 shows diffuse immunoreactivity (200x).

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.