Case Reports in Immunology / 2012 / Article / Tab 1

Case Report

Persistent Lymphadenopathy due to IgG4-Related Disease

Table 1

Differential diagnosis with pertinent laboratory findings*.

LymphomaBone marrow and lymph node biopsy performed HTLV-1+2 antibodies (nonreactive)
Castleman's disease
HHV-8 lymph node stains negative
Autoimmune Lymphoproliferative syndromeLess than 1.5% double negative (CD4−CD8−) T-cell count on cytometry
Mycobacterial infection AFB culture of lymph node (negative)
Systemic lupus erythematosusANA panel (1 : 160)
Anti-dsDNA and anti-Sm antibodies (negative)
Complement levels C3, C4 within normal range
Viral infections
EBV (nuclear Ag IgG positive, viral capsid IgG positive, viral capsid IgM negative),
CMV (IgM negative, IgG negative), parvovirus B19 (IgM negative, IgG negative),
Hepatitis (HBs Ag negative, HBc Ab negative, HBs Ab negative, HCV Ab negative)
Cat scratch disease Bartonella panel (negative)
Sjögren's syndromeSSA/SSB (negative)

*HTLV-1+2: human T-lymphotropic virus type I and II, HHV-8: human herpes virus 8; AFB: acid-fast bacilli, ANA: antinuclear antibodies, Anti-dsDNA: antidouble-stranded DNA, Anti-Sm: anti-Smith; EBV = Epstein-Barr virus, CMV: cytomegalovirus, HBs Ag = hepatitis B surface antigen, and HBc Ab: hepatitis B core antibody IgG, HBs Ab = hepatitis B surface antibody, HCV Ab: hepatitis C virus antibody, SSA: anti-Ro/SSA antibodies, and SSB: anti-La/SSB antibodies.

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