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Case Reports in Immunology
Volume 2012, Article ID 684247, 4 pages
Case Report

Symptomatic Secondary Selective IgM Immunodeficiency in Adult Man with Undiagnosed Celiac Disease

1Leumit Health Services, Ashkelon, Israel
2Medicine B Department, Barzilai Medical Center, 78306 Ashkelon, Israel
3Allergy and Clinical Immunology Unit, Barzilai Medical Center, Barzilai Hospital, Ben Gurion University of Negev, Ashkelon, Israel
4Orthopedic Department, Meir Medical Center, Kfar Saba, Israel

Received 13 August 2012; Accepted 27 September 2012

Academic Editors: C. Pignata and A. Vojdani

Copyright © 2012 Eli Magen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Selective IgM immunodeficiency (SIgMID) is a heterogeneous disorder with no known genetic background and may occur as a primary or a secondary condition. Celiac disease has been reported in association with several humeral immunodeficiencies, including isolated severe selective IgA deficiency, panhypogammaglobulinemia, and isolated combined IgA and IgM deficiency. There are only few reported cases of pediatric and adult patients with SIgMID and celiac disease. In this paper, we describe an adult patient with a symptomatic secondary SIgMID associated with undiagnosed celiac disease, with a resolution of clinical symptoms of immunodeficiency and serum IgM normalization following a gluten-free diet.