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Case Reports in Immunology
Volume 2012, Article ID 978479, 3 pages
Case Report

Intrapleural Bortezomib for the Therapy of Myelomatous Pleural Effusion: A Case Report

11st Department of Medicine and Clinical Department of Hematology, the General Teaching Hospital, Charles University in Prague, Prague, Czech Republic
2Institute of Pathological Physiology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
3Institute of Hematology and Blood Transfusion, Prague, Czech Republic

Received 18 August 2012; Accepted 20 September 2012

Academic Editors: N. Martinez-Quiles, H. Narimatsu, M. M. Nogueras, and H. L. Trivedi

Copyright © 2012 Magdalena Klanova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Myelomatous pleural effusion (MPE) is an extremely rare manifestation of multiple myeloma (MM). We present a case of MPE in a patient with IgG-κ MM treated with intrapleural bortezomib with systemic bortezomib-based therapy. Although we observed good local response, the patient succumbed due to systemic myeloma progression.