Case Report
Increased IL-17, a Pathogenic Link between Hepatosplenic Schistosomiasis and Amyotrophic Lateral Sclerosis: A Hypothesis
| | Analyte | Reference range | Month 1 | Month 4 | Month 8 |
| | Leukocyte count (103/L) | 4.3–11.0 | 1.30 | 1.50 | 1.70 | | Lymphocytes (103/L) | 1.0–3.7 | 0.50 | 0.70 | 0.70 | | CD4 T cells % | 31–60 | 50 | | 53 | | CD4 T cells (/L) | 410–1590 | 311 | | 315 | | Hemoglobin (g/dL) | 12–16 | 12.9 | 13.4 | 13.8 | | Platelet count (103/L) | 140–450 | 36 | 33 | 51 | | PT INR | <1.20 | 1.49 | 1.44 | 1.22 | | PTT RATIO | <1.20 | 1.21 | 1.15 | 1.05 | | CRP (mg/dL) | <0.50 | 1.4 |
0.01 | 0.03 | | -GT (U/L) | <60 | 157 | 246 | 100 | | AST (IU/liter) | <40 | 56 | 33 | 19 | | ALT (IU/liter) | <40 | 59 | 87 | 17 | | Gamma-globulin (%) | 8–16.7 | 19.6 | 14.6 | 12.1 | | IgE (IU/mL) | <120 | 81 | 175 | 63 | | Vitamin B12 (pg/mL) | 191–663 | | 1.057 | | | Folic acid (ng/mL) | 4.6–18.7 | | 3.89 | | | 25-OH-vitamin D (ng/mL) | 31–100 | 14 | | | | CPK (IU/liter) | 40–230 | 1,277 | 253 | 84 | | ANA titer | <1 : 80 | 1 : 320 | 1 : 160 | 1 : 320 | | C3 (mg/dL) | 79–152 | 68 | 73 | 78 | | C4 (mg/dL) | 16–38 | 12 | 11 | 12 | | Lupus anticoagulant panel | | | | | | aPTT-low phospholipid | <1.15 | 0.85 | | 0.66 | | DRVVT ratio | <1.10 | 1.20 | | 1.14 | | Anticardiolipin-Ab | | positive | | | | Schistosoma-Ab | | | positive | |
|
|
HIV-Ab, HTLV-I/II-Ab, HAV-IgM, HBs-Ag, HCV-Ab, HEV-Ab, CMV-IgM, TPPA, Toxoplasma-Ab, EBV-DNA, Plasmodium falciparum-Ag, and emoscopy for plasmodia: all negative.
Values out of the reference range are in bold.
ALT: alanine transaminase; AST: aspartate transaminase; ANA: antinuclear antibodies; CPK: creatine phosphokinase; CRP. C-reactive protein; DRVVT: dilute viper venome time; -GT: -glutamyltransferase; PT: prothrombine time; HTLV-I/II: human T lymphotropic virus I/II; PTT: partial thromboplastine time; and TPPA: Treponema pallidum particle agglutination.
|
