Immunodeficiency in a Child with Rapadilino Syndrome: A Case Report and Review of the Literature

Table 1

Immunological work-up.

			Normal values
White blood cells	4,7 × 10^3/mm^3		4,0–10,0 × 10^3/mm^3
Neutrophils	2,8 × 10^3/mm^3		1,5–8,5 × 10^3/mm^3
Lymphocytes	1,0 × 10^3/mm^3		2,3–5,6 × 10^3/mm^3
Immunoglobulin G	2,5 g/L		4,0–11,0 g/L
Immunoglobulin A	1,01 g/L		0,1–1,6 g/L
Immunoglobulin M	0,75 g/L		0,5–1,8 g/L
CD3+	411/mm^3		900–4500/mm^3
CD4+	279/mm^3		500–2400/mm^3
CD4RA	140/mm^3
CD4RO	139/mm^3
CD8	124/mm^3		300–1600/mm^3
CD8RA	52/mm^3
CD8RO	72/mm^3
CD25+CD127−FoxP3+	0
CD19	84/mm^3		200–1300/mm^3
CD3−CD16+CD56+	5/mm^3		100–1000/mm^3
Response of T cells to PHA	low
	Before vaccination	After vaccination	Normal values
Anti-pneumococcal AB	<3 IE/mL	<3 IE/mL	>19/mL
Anti-tetanos AB	<0.01 IE/mL	0.1 IE/mL	>0.1 IE/mL
Anti-poliovirus AB	Absent	Present
Anti-rubella AB	300 IE	—	Positive
Anti-mumps AB	Negative	—	Positive