Brain Abscess and Keratoacanthoma Suggestive of Hyper IgE Syndrome

Table 1

Assessment by NIH scoring system with clinical and laboratory tests [4].

Clinical and laboratory finding	Results	Points
Highest serum IgE level (IU/mL)	1,001–2,000	8
Skin abscesses	1-2	2
Pneumonia (episodes over lifetime)	None	0
Parenchymal lung anomalies	Absent	0
Retained primary teeth	>3	8
Scoliosis, maximum curvature	15°–20°	4
Fractures with minor trauma	None	0
Highest eosinophil count (cells/μL)	>800	6
Characteristic face	Mildly present	2
Midline anomaly	Absent	0
Newborn rash	Absent	0
Eczema (worst stage)	Mild	1
Upper respiratory infections per year	1-2	0
Candidiasis	Fingernails	2
Other serious infections	Severe	4
Fatal infection	Absent	4
Hyperextensibility	Absent	0
Lymphoma	Absent	0
Increased nasal width	<1 SD	0
High palate	Absent	0
Young-age correction	>5 years	0
Total		41