In Vitro Fertilization Using Luteinizing Hormone-Releasing Hormone Injections Resulted in Healthy Triplets without Increased Attack Rates in a Hereditary Angioedema Case
Table 1
The schema of therapies.
Period
Therapy
Dosage and reasons of dosage changes
Attack frequency
Diagnosis (2004), 2013
Danazol peroral
50–200 mg/day (according to the patient’s symptoms)
Abdominal attacks (every month before her menstrual cycle)
2013-2014 (in vitro fertilization therapies)
IV (intravenous) pdC1INH
1000 U/twice a week (LHRH injections were repeated four times. Each time LHRH was injected, and an extra dosage of 1000 U pdC1INH was administered)
No attack
2014-2015 (pregnancy < 20th week)
IV pdC1INH
1000 U every 2 days
No attack
2014-2015 (>20th week pregnancy-cesarean section)
IV pdC1-INH
1500 U every 2 days (She gained extra 20 kg weight) (Before and 12 hours after cesarean section, extra 1000 U pdC1INH was administered)
No attack
Postpartum period and breastfeeding (4 months)
IV pdC1INH
1000 U/twice a week (each abdominal attack was treated with extra 1000 U pdC1INH)
