On Two Cases with Autosomal Dominant Hyper IgE Syndrome: Importance of Immunological Parameters for Clinical Course and Follow-Up

Table 4

Serum levels of cytokines investigated in Patients 1 and 2.

Cytokine	Concentration (pg/ml)
	Patient 1		Patient 2				Reference range
	At the time of diagnosis, without prophylactic treatment	After 2 y of prophylactic treatment	At the time of diagnosis, without prophylactic treatment	After 4 y of prophylactic treatment	After 5 y of prophylactic treatment	After 6 y of prophylactic treatment
IFN-gamma	143.85	14.5	244.37	6.47	17.75	3.92	8.08 ± 25.32
IL-12p70	54.46	0.0	50.96	2.83	2.63	0.0	0.90 ± 1.26
IL-13	1.17	0.0	3.81	0.0	0.70	0.56	0.09 ± 0.26
IL1beta	1.76	0.0	47.04	1.32	1.76	0.0	0.09 ± 0.23
IL-2	0.0	0.0	404.17	0.87	7.93	0.0	0.57 ± 1.41
IL-4	8.42	0.0	217.52	0.0	6.59	0.0	0.0
IL-5	1.22	0.0	10.39	0.0	0.61	0.0	0.94 ± 1.26
IL-6	25.71	0.0	18.46	1.70	1.70	3.12	0.07 ± 0.24
TNF-alpha	2.09	0.0	9.64	0.0	6.26	4.17	0.08 ± 0.28
GM-CSF	5.11	0.0	31.46	0.0	23.39	0.0	0.64 ± 1.34
IL-18	113.32	16.0	43.61	22.4	43.52	4.53	1.67 ± 1.75

The values are laboratory specific based on healthy controls tested.