Passenger Lymphocyte Syndrome and Autoimmune Hypothyroidism Following Hematopoietic Stem Cell Transplantation

Figure 1

Onset of severe immune hemolysis and autoimmune thyroiditis in a HSCT recipient. (a): Hemoglobin level and timeline of red blood cell (RBC) transfusions up to day +12 after HSCT. Note that a severe hemolytic transfusion reaction occurred after transfusion of group A iRBCs on day +10, which prompted an emergent red blood cell exchange. (b): Free-T4 (fT4) and (c) thyroid-stimulating hormone (TSH) levels up to day +2500 post-HSCT. Note the appearance of antithyroglobulin (Anti-TG) in the serum followed by the peak of TSH and the drop of fT4, indicating autoimmune thyroiditis.

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