Cesar Daniel Alonso-Bello

Mar&#xed;a del Carmen Jim&#xe9;nez-Mart&#xed;nez

Mar&#xed;a Eugenia Vargas-Cama&#xf1;o

Sagrario Hierro-Orozco

Mario Alberto Ynga-Durand

Laura Berr&#xf3;n-Ruiz

Julio C&#xe9;sar Alc&#xe1;ntara-Montiel

Leopoldo Santos-Argumedo

Diana Andrea Herrera-S&#xe1;nchez

Fernando Lozano-Pati&#xf1;o

Mar&#xed;a Isabel Castrej&#xf3;n-V&#xe1;zquez

Erratum to &#x201c;Partial and Transient Clinical Response to Omalizumab in IL-21-Induced Low STAT3-Phosphorylation on Hyper-IgE Syndrome&#x201d;

Background. Henoch&#x2013;Sch&#xf6;nlein purpura (HSP) is an uncommon syndrome that mostly occurs in children, in whom it is frequently triggered by infections. In contrast, HSP in adults is more frequently of neoplastic origin. Case Presentation. We report HSP associated with a locally advanced lung squamous cell carcinoma that was considered a paraneoplastic syndrome. Systemic corticosteroids were given because a kidney biopsy revealed active glomerulonephritis. Concomitant chemoradiotherapy achieved a partial response of the lung tumor. Consolidation immunotherapy (programmed death protein-1-ligand-1 (PD-L1) inhibitor) was cancelled because HSP is known to be an autoimmune vasculitis, and long-term corticosteroid therapy was pursued. Conclusion. Further prospective studies are needed to evaluate the effect of anti-PD-(L) 1 immunotherapies on autoimmune manifestations.

&#xc9;lo&#xef;se Philippe

Aude Barnier

Juliette Menguy

Gilles Robinet

Gilles Qu&#xe9;r&#xe9;

Francis Couturaud

Renaud Descourt

Henoch&#x2013;Sch&#xf6;nlein Purpura Associated with Lung Cancer: When Paraneoplastic Manifestations Impede Oncological Management

Mycobacterium marinum is a free-living nontuberculous mycobacterium that is widely distributed in freshwater and seawater around the world. Granulomatous skin infection from M. marinum in people who are exposed to fish or aquatic environments is a rare condition known as fish tank granuloma. The granuloma mainly occurs on the skin of the upper limb, in a few cases on the face, and rarely in the nasal cavity. We describe a case of M. marinum infection that presented as a nasal cavity mass. A 57-year-old woman who was receiving infliximab for psoriatic arthritis visited our hospital with a complaint of right nasal obstruction. A granulomatous mass with an irregular surface was found in the anterior part of the right nasal cavity. Tissue biopsy revealed granulation tissue. Since the application of steroid ointment did not reduce the size of the mass, the tumor was resected under local anesthesia, and the base was cauterized. The pathological finding was an inflammatory granuloma with negative Ziehl&#x2013;Neelsen staining. The granuloma recurred 3 months after resection. The interferon-gamma release assay (IGRA) test was positive, and therefore, a mycobacterial tissue culture test was performed because of suspected nasal tuberculosis, which identified M. marinum. The nasal cavity mass disappeared 2 months after the administration of minocycline, followed by clarithromycin, and subsequent discontinuation of infliximab. M. marinum infection can cause an intranasal mass. IGRA and the mycobacterial tissue culture test are useful for diagnosis. As in this case, the nasal lesion may be excised as an inflammatory nasal granuloma, and therefore, there may be many more &#x201c;hidden&#x201d; cases of M. marinum infection. If nasal granulation is present, the possibility of M. marinum infection should be considered.

Motoki Sekine

Fumiyuki Goto

Kosuke Saito

Shoji Kaneda

Hikaru Yamamoto

Tomoaki Murakami

Takahide Hamano

Kenji Okami

Fish Tank Granuloma Presenting as a Nasal Cavity Mass

Severe combined immunodeficiency (SCID) comprises a heterogeneous group of inherited immunologic disorders with profound defects in cellular and humoral immunity. SCID is the most severe PID and constitutes a pediatric emergency. Affected children are highly susceptible to bacterial, viral, fungal, and opportunistic infections with life-threatening in the absence of hematopoietic stem cell transplantation. We report here two cases of SCID. The first case is a girl diagnosed with SCID at birth based on her family history and lymphocyte subpopulation typing. The second case is a 4-month-old boy with a history of recurrent opportunistic infections, BCGitis, and failure to thrive, and the immunology workup confirms a SCID phenotype. The genetic study in the two cases revealed a novel mutation in the RAG2 gene, c.826G&#x2009;&#x3e;&#x2009;A (p.Gly276Ser), in a homozygous state. The novel mutation in the RAG2 gene identified in our study may help the early diagnosis of SCID.

Ibtihal Benhsaien

Fatima Ailal

Khadija Elazhary

Jalila El bakkouri

Abdallah Badou

Ahmed Aziz Bousfiha

Severe Combined Immunodeficiency Disorder due to a Novel Mutation in Recombination Activation Gene 2: About 2 Cases

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Case Reports in Immunology publishes case reports and case series related to allergies, immunodeficiencies, autoimmune diseases, immune disorders, cancer immunology and transplantation immunology.

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Case Reports in Immunology

Table of Contents

Table of Contents: 2021

Erratum to “Partial and Transient Clinical Response to Omalizumab in IL-21-Induced Low STAT3-Phosphorylation on Hyper-IgE Syndrome”

Henoch–Schönlein Purpura Associated with Lung Cancer: When Paraneoplastic Manifestations Impede Oncological Management

Fish Tank Granuloma Presenting as a Nasal Cavity Mass

Severe Combined Immunodeficiency Disorder due to a Novel Mutation in Recombination Activation Gene 2: About 2 Cases