TY - JOUR A2 - Ghate, M. A2 - Bush, L. M. A2 - Horrocks, P. A2 - Stringer, E. M. A2 - Sena, A. C. AU - Grabmeier-Pfistershammer, K. AU - Poeppl, W. AU - Brunner, P. M. AU - Rappersberger, K. AU - Rieger, A. PY - 2012 DA - 2012/12/17 TI - Clinical Challenges in the Management of Leishmania/HIV Coinfection in a Nonendemic Area: A Case Report SP - 787305 VL - 2012 AB - We report on a 37-year-old male HIV-positive patient with generalized cutaneous leishmaniasis undiagnosed for several years. Upon presentation, visceral leishmaniasis was diagnosed in addition to cutaneous manifestation of the disease. Over a period of three years, several different treatment regimens including liposomal amphotericin B, liposomal amphotericin B with miltefosine, liposomal amphotericin B with interferon, and pentamidine combined fluconazole and allopurinol were applied until Leishmania PCR from blood turned negative. This case supports the necessity of multidrug combinational and sequential therapy over a very prolonged period of time in severely immunosuppressed patients infected with Leishmania and highlights the tremendous individual but also economic burden of this disease. SN - 2090-6625 UR - https://doi.org/10.1155/2012/787305 DO - 10.1155/2012/787305 JF - Case Reports in Infectious Diseases PB - Hindawi Publishing Corporation KW - ER -