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Case Reports in Infectious Diseases
Volume 2014, Article ID 142428, 9 pages
Case Report

Failed Reverse Total Shoulder Arthroplasty Caused by Recurrent Candida glabrata Infection with Prior Serratia marcescens Coinfection

1The University of Utah Department of Orthopaedic Surgery, Salt Lake City, UT 84108, USA
2Intermountain Medical Center, Salt Lake City, UT 84157, USA
3Utah Orthopaedic Specialists, Salt Lake City, UT 84107, USA
4Alpine Internal Medicine, Salt Lake City, UT 84102, USA
5St. Marks Medical Center, Salt Lake City, UT 84124, USA
6The University of Utah Department of Internal Medicine, Salt Lake City, UT 84132, USA

Received 20 June 2014; Accepted 9 October 2014; Published 6 November 2014

Academic Editor: Pere Domingo

Copyright © 2014 John G. Skedros et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This report describes a 58-year-old insulin-dependent diabetic male patient who initially sustained a proximal humerus fracture from a fall. The fracture fixation failed and then was converted to a humeral hemiarthroplasty, which became infected with Candida glabrata and Serratia marcescens. After these infections were believed to be cured with antibacterial and antifungal treatments and two-stage irrigation and debridement, he underwent conversion to a reverse total shoulder arthroplasty. Unfortunately, the C. glabrata infection recurred and, nearly 1.5 years after implantation of the reverse total shoulder, he had a resection arthroplasty (removal of all implants and cement). His surgical and pharmacologic treatment concluded with (1) placement of a tobramycin-impregnated cement spacer also loaded with amphotericin B, with no plan for revision arthroplasty (i.e., the spacer was chronically retained), and (2) chronic use of daily oral fluconazole. We located only three reported cases of Candida species causing infection in shoulder arthroplasties (two C. albicans, one C. parapsilosis). To our knowledge, a total shoulder arthroplasty infected with C. glabrata has not been reported, nor has a case of a C. glabrata and S. marcescens periprosthetic coinfection in any joint. In addition, it is well known that S. marcescens infections are uncommon in periprosthetic joint infections.