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Case Reports in Infectious Diseases
Volume 2014 (2014), Article ID 201015, 2 pages
Case Report

Autoimmune Hemolytic Anemia Induced by Levofloxacin

Lebanese American University, P.O. Box 36, Byblos, Lebanon

Received 24 February 2014; Accepted 4 June 2014; Published 12 June 2014

Academic Editor: Jean-François Faucher

Copyright © 2014 Marwan Sheikh-Taha and Pascale Frenn. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Drug-induced autoimmune hemolytic anemia is a rare condition. We report the case of a 32-year-old white female who presented to the emergency department with generalized fatigue, fever, and jaundice. The patient reported using levofloxacin few days prior to presentation for urinary tract infection. The patient had evidence of hemolytic anemia with a hemoglobin of 6.7 g/dL which dropped to 5 g/dL on day 2, the direct Coombs test was positive, indirect bilirubin was 5.5 mg/dL, and LDH was 1283 IU/L. Further testing ruled out autoimmune disease, lymphoma, and leukemia as etiologies for the patient’s hemolytic anemia. Levofloxacin was immediately stopped with a gradual hematologic recovery within few days.