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Case Reports in Infectious Diseases
Volume 2015 (2015), Article ID 794109, 5 pages
Case Report

Role of GeneXpert MTB/Rif Assay in Diagnosing Tuberculosis in Pregnancy and Puerperium

1Infectious & Tropical Diseases Unit, Department of Medicine, Aminu Kano Teaching Hospital, PMB 3452, Kano 700233, Kano State, Nigeria
2Department of Medical Microbiology, Aminu Kano Teaching Hospital, PMB 3452, Kano 700233, Kano State, Nigeria
3College of Health Sciences, Bayero University, Kano, PMB 3011, Kano 700241, Kano State, Nigeria

Received 11 May 2015; Revised 22 July 2015; Accepted 27 July 2015

Academic Editor: Tomoyuki Shibata

Copyright © 2015 Zaiyad G. Habib et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Presentation of tuberculosis (TB) in pregnancy may be atypical with diagnostic challenges. Two patients with complicated pregnancy outcomes, foetal loss and live premature delivery at 5 and 7 months of gestation, respectively, and maternal loss, were diagnosed with pulmonary TB. Chest radiography and computed tomography showed widespread reticuloalveolar infiltrates and consolidation with cavitations, respectively. Both patients were Human Immunodeficiency Virus (HIV) seronegative and sputum smear negative for TB. Sputum GeneXpert MTB/Rif (Xpert MTB/RIF) was positive for Mycobacterium tuberculosis. To strengthen maternal and childhood TB control, screening with same-day point-of-care Xpert MTB/RIF is advocated among both HIV positive pregnant women and symptomatic HIV negative pregnant women during antenatal care in pregnancy and at puerperium.