Treatment of Polymicrobial Osteomyelitis with Ceftolozane-Tazobactam: Case Report and Sensitivity Testing of Isolates

Table 2

Bone penetration of cephalosporins and β-lactamase inhibitors [12].

	Time after last dose (hours)	Bone (mg/kg): serum concentration (mg/L) ratio	Method
Cephalosporins
Ceftriaxone	0.2–8	0.07–0.17	HPLC
Cefotaxime	0.75–4	0.02–0.28	Bioassay
Cefuroxime (osteomyelitis)	1	0.04–0.08	HPLC
Cefazolin	0.9	0.179	HPLC
Cefepime	1-2	0.46–0.76	HPLC
Ceftazidime (ischemic bone)	1-2	0.04–0.08	HPLC
Ceftazidime	2	0.54	Bioassay
β-Lactamase inhibitors
Clavulanic acid	1	1.14–1.76	Bioassay
Sulbactam	0.25–4	0.17–0.71	Gas chromatography
Tazobactam	1.5	0.22–0.26	HPLC

Assumed bone density of 1 kg/L was assumed if not reported.
HPLC: high-performance liquid chromatography.