Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma

Table 1

Clinical features of TB endophthalmitis/panophthalmitis cases previously described in the literature.

Authors	Year	Number of cases	Host (sex/age/immune status)	Onset	Extraocular foci of TB	Outcomes	Notes
Dvorak-Theobald [7]	1958	1	M/37/immunocompetent	2 weeks	TB adrenal gland, previous TB kidney	Enucleation	—
Arrell [8]	1967	1	M/73/immunocompetent	2 months	Old pulmonary TB (from chest film)	Evisceration	—
McMoli et al. [9]	1978	1	M/1/immunocompetent	?	Pulmonary TB	Evisceration	—
Manthey et al. [10]	1982	1	F/60/immunocompetent	?	Pulmonary TB	Enucleation	Prior steroid treatment led to temporary regression
			F/30/immunocompetent	2 months	Previous disseminated TB, active pulmonary TB	Enucleation	—
Ni et al. [11]	1982	3	M/11/immunocompetent	2 months	Abnormal chest film	Enucleation	Misdiagnosed with retinoblastoma
			F/15/immunocompetent	1 month	Abnormal chest film	Enucleation	—
Menezo et al. [12]	1987	1	F/20/HIV	3 days	None but PPD+	Evisceration	History of heroin use
Regillo et al. [13]	1991	1	F/29/immunocompetent	6 months	Pulmonary TB	Evisceration	Prior steroid treatment
Anders and Wollensak [14]	1995	1	F/36/SLE	2 months	Pulmonary TB	Enucleation	—
Biswas et al. [15]	1995	2	F/42/?	?	TB liver	Evisceration	—
			F/30/?	?	Pulmonary TB	Evisceration	Bilateral involvement
Raina et al. [16]	2000	1	F/8/immunocompetent	3 months	None but PPD+	Enucleation	—
Sheu et al. [17]	2001	2	F/75/immunocompetent	2 weeks	Pulmonary TB	Evisceration	—
			M/68/immunocompetent	2 months	Pulmonary TB (miliary TB)	Enucleation	—
Grosse et al. [18]	2002	1	M/30/immunocompetent	2 months	TB lymphadenitis (generalized), CNS tuberculoma	Evisceration	—
Sen et al. [19]	2003	1	M/4/immunocompetent	1 month	CNS tuberculoma	Evisceration	Bilateral involvement
Chawla et al. [20]	2004	1	F/12/immunocompetent	2 months	Abnormal chest film responsive to ATT	Enucleation	—
Demirci et al. [21]	2004	2	M/28/immunocompetent	3 months	TB peritonitis (later)	Evisceration	Prior steroid treatment
			F/29/immunocompetent	5 months	Granulomatous hilar lymphadenopathy, PPD+	Enucleation	Prior steroid treatment
			M/45/HIV, CD4 = 88	?	Pulmonary TB	Evisceration	—
Babu et al. [23]	2006	3	M/36/HIV, CD4 = 263	?	Pulmonary TB	Evisceration	—
			M/34/HIV, CD4 = 34	?	Pulmonary TB, abdominal TB	Evisceration	—
Mehta and Vaidya [24]	2011	1	F/77/immunocompetent	1 week	None, PPD and QFT—negative, CT chest and abdomen—normal	Regressed with ATT/vitrectomy	Underwent cataract extraction 2 months earlier
Hase et al. [25]	2015	1	M/81/steroid use	?	Pulmonary TB (miliary TB)	Regressed with ATT/vitrectomy	—

TB = tuberculosis, M = male, F = female, SLE = systemic lupus erythematosus, PPD = purified protein derivative (Mantoux) test, QFT = Quantiferon TB gold test, and ATT = antituberculous therapy.