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Case Reports in Infectious Diseases
Volume 2017, Article ID 1489210, 3 pages
Case Report

Subacute Hypophysitis with Panhypopituitarism as First Presentation of HIV and Syphilis Coinfection

Clinical Immunology Unit, Centro Hospitalar do Porto, Porto, Portugal

Correspondence should be addressed to Rute Alves; moc.liamg@sevlafietur

Received 31 July 2016; Accepted 6 March 2017; Published 16 April 2017

Academic Editor: Larry M. Bush

Copyright © 2017 Rute Alves and Margarida França. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Infection by Treponema pallidum still represents a clinical challenge due to its various forms of presentation. HIV coinfection added diversity and changed the natural history of syphilis as a systemic infection. We present a rare case of subacute hypophysitis and panhypopituitarism due to an early active neurosyphilis in a previously unknown HIV coinfected patient.