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Case Reports in Infectious Diseases
Volume 2017 (2017), Article ID 3416857, 5 pages
Case Report

Severe Thrombocytopenic Purpura in a Child with Brucellosis: Case Presentation and Review of the Literature

Child Health Department, Faculty of Medicine, University of Ioannina, Ioannina, Greece

Correspondence should be addressed to Alexandros Makis

Received 10 October 2016; Accepted 15 December 2016; Published 3 January 2017

Academic Editor: Lawrence Yamuah

Copyright © 2017 Alexandros Makis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Brucellosis is still endemic and a significant public health problem in many Mediterranean countries, including Greece. It is a multisystemic disease with a broad spectrum of clinical manifestations including hematological disorders, such as anemia, pancytopenia, leucopenia, and thrombocytopenia. Thrombocytopenia is usually moderate and attributed to bone marrow suppression or hypersplenism. Rarely, autoimmune stimulation can cause severe thrombocytopenia with clinically significant hemorrhagic manifestations. We present the case of a girl with severe thrombocytopenic purpura as one of the presenting symptoms of Brucella melitensis infection. Treatment with intravenous immunoglobulin and the appropriate antimicrobial agents promptly resolved the thrombocyte counts. A review of similar published cases is also presented.