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Case Reports in Infectious Diseases
Volume 2017, Article ID 6854913, 4 pages
Case Report

Mycoplasma Pneumonia: An Unrecognized Cause of Fever of Unknown Origin in an Adult

1Internal Medicine/Pediatrics Department, Beaumont Health, Royal Oak, MI, USA
2Internal Medicine Department, General Internal Medicine Division, Beaumont Health, Royal Oak, MI, USA
3Oakland University William Beaumont School of Medicine, Rochester, MI, USA

Correspondence should be addressed to Fatima Ali-Ahmed; ude.tnomuaeb@demha-ila.amitaf

Received 28 June 2017; Accepted 12 September 2017; Published 17 October 2017

Academic Editor: Sinésio Talhari

Copyright © 2017 Fatima Ali-Ahmed and Alexandra Halalau. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 26-year-old female was admitted for fever of unknown origin (FUO), headaches, left ankle edema, and a lower extremity rash consistent with erythema nodosum. She had no respiratory symptoms or family history of autoimmune diseases. A chest X-ray was negative for pneumonia or hilar adenopathy. Extensive autoimmune workup was negative. A chest, abdomen, and pelvis computed tomography scan was unremarkable and laboratory studies revealed no source of infection. On hospital day 5, the patient developed a mild productive cough. Her Mycoplasma pneumonia (MP) IgM was high, confirming the diagnosis of MP induced FUO. She was started on azithromycin 500 mg daily and within 24 hours her fevers and headaches resolved. Her left ankle edema and EN gradually improved over a course of a few weeks. This case report highlights the need for MP testing in the evaluation of fever of unknown origin, even in the absence of pulmonary manifestations.