Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Infectious Diseases
Volume 2017, Article ID 9028543, 5 pages
https://doi.org/10.1155/2017/9028543
Case Report

Successful Treatment of Klebsiella pneumoniae Harboring a Klebsiella pneumoniae Carbapenemase Isolated from Lumbar Wound Infection and Blood in a Patient with Hardware Retention

1Division of Infectious Diseases and Antimicrobial Stewardship, St. Francis Hospital, Roslyn, NY, USA
2The Dr. James J. Rahal, Jr. Division of Infectious Diseases, Department of Medicine, NewYork-Presbyterian/Queens, Flushing, NY, USA

Correspondence should be addressed to Carl Urban; gro.pyn@nabrumc

Received 2 June 2017; Accepted 7 August 2017; Published 17 September 2017

Academic Editor: Gernot Walder

Copyright © 2017 Alan Bulbin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Centers for Disease Control and Prevention (CDC), “Antibiotic Resistance Threats in the United States,” CDC, Atlanta, 2013.
  2. F. Perez, N. G. El Chakhtoura, K. M. Papp-Wallace, B. M. Wilson, and R. A. Bonomo, “Treatment options for infections caused by carbapenem-resistant Enterobacteriaceae: can we apply “precision medicine” to antimicrobial chemotherapy?” Expert Opinion on Pharmacotherapy, vol. 17, no. 6, pp. 761–781, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. E. M. Trecarichi and M. Tumbarello, “Therapeutic options for carbapenem-resistant Enterobacteriaceae infections,” Virulence, pp. 1–15, 2017. View at Publisher · View at Google Scholar · View at Scopus
  4. H. J. Morrill, J. M. Pogue, K. S. Kaye, and K. L. LaPlante, “Treatment options for carbapenem-resistant enterobacteriaceae infections,” Open Forum Infectious Diseases, vol. 2, no. 2, 2015. View at Publisher · View at Google Scholar
  5. A. Oliva, L. Scorzolini, D. Castaldi et al., “Double-carbapenem regimen, alone or in combination with colistin, in the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp),” Journal of Infection, vol. 74, no. 1, pp. 103–106, 2017. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Tumbarello, P. Viale, C. Viscoli et al., “Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy,” Clinical Infectious Diseases, vol. 55, no. 7, pp. 943–950, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. Z. A. Qureshi, D. L. Paterson, B. A. Potoski et al., “Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens,” Antimicrobial Agents and Chemotherapy, vol. 56, no. 4, pp. 2108–2113, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. R. K. Shields, B. A. Potoski, G. Haidar et al., “Clinical outcomes, drug toxicity and emergence of ceftazidime-avibactam resistance among patients treated for carbapenem-resistant Enterobacteriaceae infections,” Clinical Infectious Diseases, vol. 63, no. 12, pp. 1615–1618, 2016. View at Publisher · View at Google Scholar
  9. F. Krapp, J. L. Grant, S. H. Sutton, E. A. Ozer, and V. O. Barr, “Treating complicated carbapenem-resistant enterobacteriaceae infections with ceftazidime/avibactam: a retrospective study with molecular strain characterisation,” International Journal of Antimicrobial Agents, vol. 49, no. 6, pp. 770–773, 2017. View at Publisher · View at Google Scholar
  10. R. K. Shields, C. J. Clancy, B. Hao et al., “Effects of Klebsiella pneumoniae carbapenemase subtypes, extended-spectrum β-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniae,” Antimicrobial Agents and Chemotherapy, vol. 59, no. 9, pp. 5793–5797, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. J.-M. Pagès, S. Peslier, T. A. Keating, J.-P. Lavigne, and W. W. Nichols, “Role of the outer membrane and porins in susceptibility of β-lactamase-producing Enterobacteriaceae to ceftazidime-avibactam,” Antimicrobial Agents and Chemotherapy, vol. 60, no. 3, pp. 1349–1359, 2016. View at Publisher · View at Google Scholar · View at Scopus
  12. R. M. Humphries and P. Hemarajata, “Resistance to ceftazidime-avibactam in klebsiella pneumoniae due to porin mutations and the increased expression of KPC-3,” Antimicrobial Agents and Chemotherapy, vol. 61, no. 6, Article ID e00537-17, 2017. View at Publisher · View at Google Scholar
  13. J. Perlroth, M. Kuo, J. Tan, A. S. Bayer, and L. G. Miller, “Adjunctive use of rifampin for the treatment of Staphylococcus aureus infections: a systematic review of the literature,” Archives of Internal Medicine, vol. 168, no. 8, pp. 805–819, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. W. Zimmerli, A. F. Widmer, M. Blatter, R. Frei, and P. E. Ochsner, “Role of rifampin for treatment of orthopedic implant-related staphylococcal infections,” Journal of the American Medical Association, vol. 279, no. 19, pp. 1537–1541, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Urban, N. Mariano, and J. J. Rahal, “In vitro double and triple bactericidal activities of doripenem, polymyxin B, and rifampin against multidrug-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli,” Antimicrobial Agents and Chemotherapy, vol. 54, no. 6, pp. 2732–2734, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Bratu, P. Tolaney, U. Karumudi et al., “Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: molecular epidemiology and in vitro activity of polymyxin B and other agents,” Journal of Antimicrobial Chemotherapy, vol. 56, no. 1, pp. 128–132, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. R. M. Humphries, S. Yang, P. Hemarajata et al., “First report of ceftazidime-avibactam resistance in a KPC-3-expressing Klebsiella pneumoniae isolate,” Antimicrobial Agents and Chemotherapy, vol. 59, no. 10, pp. 6605–6607, 2015. View at Publisher · View at Google Scholar · View at Scopus