Case Report

Cerebral Venous Thrombosis as Rare Presentation of Herpes Simplex Virus Encephalitis

Table 1

Comparison between cases of HSV encephalitis associated with CVT reported in the literature.

Case numberYear of publicationPatient’s agePatient’s sexHSV clinical presentationDiagnosis of CVTRisk factors identified for venous thromboembolismCVT treatmentOutcome

Case 1 [4]200548MaleSeizures, high fever, history of headaches, and flu-like symptomsSimultaneousNoneLMWH acute phase followed by warfarin for 6 monthsFavourable, no deficits
Case 2 [5]201230FemaleSeizures, high fever, confusion, and headachesSimultaneousPregnancyLMWH until deliveryFavourable, no deficits
Case 3 [6]201831MaleSeizures, headache, and photofobiaDay 6 of treatment: worsening headache, upper limb weaknessNoneIntravenous heparin acute phase followed by warfarin for 1 yearFavourable, no deficits
Our case44MaleSeizures, low fever, and history of headachesSimultaneousFactor V Leiden heterozygosityLMWH acute phase followed by rivaroxaban 1 yearFavourable, no deficits

LMWH: low-molecular-weight heparin.