Case Report

Brevibacterium Bacteremia in the Setting of Pyogenic Liver Abscess: A Case Report with Accompanying Literature Review

Table 1

Clinical summaries of Brevibacterium bacteremia case reports.

Author (year)SexAgeBrevibacterium speciesUnderlying conditionClinical courseTreatment regimen (duration)Presence of an indwelling catheterOutcome

McCaughey and Damani (1991) [8]M40epidermidisZollinger–Ellison SyndromeVomiting, weight loss, recurrent duodenal ulceration, pyloric outflow obstructionErythromycin, TLCa removalYes- indwelling subclavian TLCa for TPNbSurvived
Lina et al. (1994) [9]M19Not specifiedLymphoblastic LymphomaFever, retroocular pain; recurrence after 1 monthIV teicoplanin, amikacin for 20 days; teicoplanin x21 days, TLCa removalYes- for chemotherapy; type not specifiedRecurrence; survived
Reinert et al. (1995) [10]M25caseiTesticular choriocarcinomaFever, pancytopeniaIV piperacillin, teicoplanin for 10 days; piperacillin, tobramycin for 10 daysYes- TLCa for chemotherapyRecurrence; survived
Kaukoranta-Tolvanen et al. (1995) [11]F56caseiNon-Hodgkin lymphomaFever, pancytopenia, CRPc 42 mg/dLNot specifiedYes- TLCa for chemotherapyRecurrence; survived
Castagnola et al. (1997) [12]------caseiNeuroblastomaFever, ANCd>1000 cm3Not specified; TLCa removedYes- Broviac® for chemotherapySurvived
Brazzola et al. (2000) [13]F18caseiAcquired Immunodeficiency Syndrome (AIDS)Fever, dehydrationIV Unasyn, switched to ciprofloxacin for 14 days; TLCa removedYes- Port-A Cath® for PPNeSurvived
Ogunc et al. (2002) [14]---60Not specifiedChronic Lymphocytic Leukemia (CLL)Fever following fludarabine chemotherapy, anemiaIV ceftazidime, amikacin; switched to vancomycinNot specifiedSurvived
Janda et al. (2003) [7]M34caseiAcquired Immunodeficiency Syndrome (AIDS)CD4<50, known CMV retinitis, oropharyngeal candidiasis, neutropenic fever, malaiseIV vancomycin for 8 days, ceftazidime (stopped); TLCa removedYes- Hickman® catheter for long-term gancylovir infusionSurvived
Beukinga et al. (2004) [15]F43caseiCrohn’s DiseaseChronic fistulae, total colectomy, fever, WBCf 3300, CRPc 5.8 mg/dLIV vancomycin for 15 days, TLCa remained; IV Unasyn, Merrem, amikacin, TLCa removedYes- Port-A Cath® for PPNeRecurrence (at 5 months); died
Beukinga et al. (2004) [15]M31caseiNot specifiedFever, WBCf 4700, CRPc (-)IV vancomycin for 15 days, TLCa remained; same treatmentYes- Hickman® catheter for hemodialysisRecurrence (at 5 months); survived
Ulrich et al. (2006) [3]F62caseiSevere pulmonary hypertensionFlu-like symptoms, productive cough, chills, fever, hypoxemia, CRPc 38 mg/dLIV vancomycin for 10 days, then moxifloxacin for 20 days, TLCa removedYes- TLCa for iloprost infusionSurvived
Bal et al. (2015) [16]M6caseiAcute Lymphoblastic Leukemia (ALL), B cell typeHerpes zoster infection, pancytopenia, neutropenic fever, ANCd 387 mm3/uL, CRPc 6.1 mg/dLIV Zosyn, vancomycin for 10 days, TLCa remainedYes- Hickman® catheter for chemotherapySurvived
Bonavila Juan et al. (2017) [17]M60caseiChild–Pugh C alcoholic cirrhosis, aortic stenosis; development of aortic valve endocarditis and insufficiency with recurrenceTremor, altered mental status, fever, pustular rash; decompensated cirrhosis, coagulopathy, thrombocytopenia, 1.5 cm aortic valve vegetation seen on TEEg; right arm weakness, septic emboliOral Levaquin for 10 days, then norfloxacin; IV vancomycin for 4 weeks; IV vancomycin for 10 days, daptomycin for 6 daysNot specifiedRecurrence (30 days, 90 days); died
Vecten et al. (2017) [18]M4massilienseCongenital methylmelonic acidemiaFever, cough, emesis, left ear discharge, WBCf 9400uL, CRPc (-), oxalic acid 0.020 mmol/LIntra-auricular ofloxacin for 8 daysYes- gastrostomy tube presentSurvived
Magi et al. (2018) [19]F48CaseiBilateral breast cancer requiring mastectomy, chemotherapy, radiation, and salpingoophorectomyFever, myalgia, CRPc 5.97 mg/dLIV teicoplanin for 7 days, linezolid for 7 days, TLCa removedYes- transjugular Port-A-Cath® from prior chemotherapy treatmentSurvived
Asai et al. (2019) [5]F94paucivoransType 2 diabetes mellitus, congestive heart failureFever, decreased oral intake, appetite loss, thrombocytopenia, CRPc (-)IV Merrem, teicoplanin for 14 daysNot presentSurvived
Our CaseM71Unable to speciatePoorly controlled type 2 diabetes mellitus, pyogenic liver abscessAltered mental status, abdominal pain, decreased oral intake, WBCf 12,000, anemia, hyponatremia, hyperglycemia, HbA1c 12.2, acetone (-), CRPc 50 mg/dL, procalcitonin 8.16IV Unasyn for 3 weeks, abscess drainageNot presentSurvived

M = male, F = female; aTLC = triple lumen catheter; bTPN = total parenteral nutrition, cCRP = c-reactive protein, dANC = absolute neutrophil count, ePPN = partial parenteral nutrition, fWBC = white blood cell, gTEE = transesophageal echocardiogram.