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Author (year) | Sex | Age | Brevibacterium species | Underlying condition | Clinical course | Treatment regimen (duration) | Presence of an indwelling catheter | Outcome |
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McCaughey and Damani (1991) [8] | M | 40 | epidermidis | Zollinger–Ellison Syndrome | Vomiting, weight loss, recurrent duodenal ulceration, pyloric outflow obstruction | Erythromycin, TLCa removal | Yes- indwelling subclavian TLCa for TPNb | Survived |
Lina et al. (1994) [9] | M | 19 | Not specified | Lymphoblastic Lymphoma | Fever, retroocular pain; recurrence after 1 month | IV teicoplanin, amikacin for 20 days; teicoplanin x21 days, TLCa removal | Yes- for chemotherapy; type not specified | Recurrence; survived |
Reinert et al. (1995) [10] | M | 25 | casei | Testicular choriocarcinoma | Fever, pancytopenia | IV piperacillin, teicoplanin for 10 days; piperacillin, tobramycin for 10 days | Yes- TLCa for chemotherapy | Recurrence; survived |
Kaukoranta-Tolvanen et al. (1995) [11] | F | 56 | casei | Non-Hodgkin lymphoma | Fever, pancytopenia, CRPc 42 mg/dL | Not specified | Yes- TLCa for chemotherapy | Recurrence; survived |
Castagnola et al. (1997) [12] | --- | --- | casei | Neuroblastoma | Fever, ANCd>1000 cm3 | Not specified; TLCa removed | Yes- Broviac® for chemotherapy | Survived |
Brazzola et al. (2000) [13] | F | 18 | casei | Acquired Immunodeficiency Syndrome (AIDS) | Fever, dehydration | IV Unasyn, switched to ciprofloxacin for 14 days; TLCa removed | Yes- Port-A Cath® for PPNe | Survived |
Ogunc et al. (2002) [14] | --- | 60 | Not specified | Chronic Lymphocytic Leukemia (CLL) | Fever following fludarabine chemotherapy, anemia | IV ceftazidime, amikacin; switched to vancomycin | Not specified | Survived |
Janda et al. (2003) [7] | M | 34 | casei | Acquired Immunodeficiency Syndrome (AIDS) | CD4<50, known CMV retinitis, oropharyngeal candidiasis, neutropenic fever, malaise | IV vancomycin for 8 days, ceftazidime (stopped); TLCa removed | Yes- Hickman® catheter for long-term gancylovir infusion | Survived |
Beukinga et al. (2004) [15] | F | 43 | casei | Crohn’s Disease | Chronic fistulae, total colectomy, fever, WBCf 3300, CRPc 5.8 mg/dL | IV vancomycin for 15 days, TLCa remained; IV Unasyn, Merrem, amikacin, TLCa removed | Yes- Port-A Cath® for PPNe | Recurrence (at 5 months); died |
Beukinga et al. (2004) [15] | M | 31 | casei | Not specified | Fever, WBCf 4700, CRPc (-) | IV vancomycin for 15 days, TLCa remained; same treatment | Yes- Hickman® catheter for hemodialysis | Recurrence (at 5 months); survived |
Ulrich et al. (2006) [3] | F | 62 | casei | Severe pulmonary hypertension | Flu-like symptoms, productive cough, chills, fever, hypoxemia, CRPc 38 mg/dL | IV vancomycin for 10 days, then moxifloxacin for 20 days, TLCa removed | Yes- TLCa for iloprost infusion | Survived |
Bal et al. (2015) [16] | M | 6 | casei | Acute Lymphoblastic Leukemia (ALL), B cell type | Herpes zoster infection, pancytopenia, neutropenic fever, ANCd 387 mm3/uL, CRPc 6.1 mg/dL | IV Zosyn, vancomycin for 10 days, TLCa remained | Yes- Hickman® catheter for chemotherapy | Survived |
Bonavila Juan et al. (2017) [17] | M | 60 | casei | Child–Pugh C alcoholic cirrhosis, aortic stenosis; development of aortic valve endocarditis and insufficiency with recurrence | Tremor, altered mental status, fever, pustular rash; decompensated cirrhosis, coagulopathy, thrombocytopenia, 1.5 cm aortic valve vegetation seen on TEEg; right arm weakness, septic emboli | Oral Levaquin for 10 days, then norfloxacin; IV vancomycin for 4 weeks; IV vancomycin for 10 days, daptomycin for 6 days | Not specified | Recurrence (30 days, 90 days); died |
Vecten et al. (2017) [18] | M | 4 | massiliense | Congenital methylmelonic acidemia | Fever, cough, emesis, left ear discharge, WBCf 9400uL, CRPc (-), oxalic acid 0.020 mmol/L | Intra-auricular ofloxacin for 8 days | Yes- gastrostomy tube present | Survived |
Magi et al. (2018) [19] | F | 48 | Casei | Bilateral breast cancer requiring mastectomy, chemotherapy, radiation, and salpingoophorectomy | Fever, myalgia, CRPc 5.97 mg/dL | IV teicoplanin for 7 days, linezolid for 7 days, TLCa removed | Yes- transjugular Port-A-Cath® from prior chemotherapy treatment | Survived |
Asai et al. (2019) [5] | F | 94 | paucivorans | Type 2 diabetes mellitus, congestive heart failure | Fever, decreased oral intake, appetite loss, thrombocytopenia, CRPc (-) | IV Merrem, teicoplanin for 14 days | Not present | Survived |
Our Case | M | 71 | Unable to speciate | Poorly controlled type 2 diabetes mellitus, pyogenic liver abscess | Altered mental status, abdominal pain, decreased oral intake, WBCf 12,000, anemia, hyponatremia, hyperglycemia, HbA1c 12.2, acetone (-), CRPc 50 mg/dL, procalcitonin 8.16 | IV Unasyn for 3 weeks, abscess drainage | Not present | Survived |
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