A Giant Mucinous Adenocarcinoma Arising within a Villous Adenoma of the Urachus: Case Report and Review of the Literature
(a) Villous adenoma of the bladder with complex branching papillary structures, that are distended due to the presence of the exophytic mass in the lumen. There is no invasion into the underlying bladder wall ‘ (Hematoxylin Eosin stain, original magnification 50) Inset: Higher magnification shows that the fibrovascular stalks of the adenoma are lined by pseudostratified mucinous epithelium with only mild degree of anisokaryosis. (Hematoxylin Eosin stain, original magnification 200), (b) Urachal mucinous adenocarcinoma characterized by small sheets and nests of columnar mucinous cells floating in extracellular mucin. (Hematoxylin Eosin stain, original magnification 50), (c) The cysts are lined with urachal mucinous adenocarcinoma with invasion in the bladder wall. (Hematoxylin Eosin stain, original magnification 25), (d) Detail of papillary projections coated with columnar mucinous cells with pseudostratification, nuclear hyperchromasia and crowding, and goblet cells. (Hematoxylin Eosin stain, original magnification 200).
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