Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2010, Article ID 426970, 6 pages
http://dx.doi.org/10.1155/2010/426970
Case Report

Goodpasture's Syndrome and Silica: A Case Report and Literature Review

1UCLA School of Medicine-Occupational Medicine, 2811 Wilshire Boulevard, Suite 510, Santa Monica, CA 90403, USA
2James Dahlgren Medical, 2811 Wilshire Boulevard, Suite 510, Santa Monica, CA 90403, USA

Received 31 March 2010; Revised 15 July 2010; Accepted 24 August 2010

Academic Editor: Roland M. du Bois

Copyright © 2010 James Dahlgren et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report a case of Goodpasture's syndrome following chronic low level and an acute, high level of exposure to crystalline silica. A 38-year-old male tilesetter was admitted to the emergency room with dyspnea and respiratory failure. He reported that his symptoms had developed over the previous week after inhaling a large amount of dust while dry-sanding and sweeping a silica-based product used to fill cracks in a cement floor. Over the following days, his pulmonary function declined and he developed acute renal failure. Tests of antiglomerular basement membrane antibody were positive and renal biopsy revealed global glomerulonephritis. He was diagnosed with Goodpasture's syndrome and treated with steroids, plasmapheresis, and hemodialysis. This man had a history of childhood asthma and a remote, one pack-year history of cigarette use. He used the flooring product for seven years prior to the inciting event, however, previous jobs had utilized significantly smaller amounts. Goodpasture's syndrome and other autoimmune diseases have been reported in association with silica exposure. The acute onset following high level silica exposure in this previously healthy man, suggest that clinicians should investigate silica exposure as a causal factor in cases of Goodpasture's syndrome.