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Case Reports in Medicine
Volume 2010, Article ID 472389, 4 pages
http://dx.doi.org/10.1155/2010/472389
Case Report

Prolonged Neuromuscular Blockade Following Succinylcholine Administration to a Patient with a Reduced Butyrylcholinesterase Activity

1Department for Anaesthesiology, Canisius-Wilhelmina Hospital, C40-01 Postbus 9015, 6500 GS Nijmegen, The Netherlands
2Department for Anaesthesiology, University Hospital Basel 4301 Basel, Switzerland

Received 20 January 2010; Accepted 30 April 2010

Academic Editor: Albert Dahan

Copyright © 2010 Ivo F. Panhuizen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This case is about a 48-year-old woman known with a reduced butyrylcholinesterase activity, who developed prolonged neuromuscular blockade following the unintentional administration of succinylcholine. We took the opportunity to monitor the development of neuromuscular function during this period and blood samples were taken for molecular genetic analysis and for quantitative and qualitative analysis since not all causative mutations are functionally characterized. Reduced butyrylcholinesterase activity is discussed in many aspects. Clinical considerations are suggested concerning genetic counselling.