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Case Reports in Medicine
Volume 2010, Article ID 708348, 3 pages
Case Report

Relapsed Mantle Cell Lymphoma Presenting as “Sister Mary Joseph Nodule”

1Department of Internal Medicine, University of Washington, Box 39892. 325 Ninth Ave., Seattle, WA 98104, USA
2Clinical Research Division, Fred Hutchinson Research Center, Seattle, WA, USA
3Seattle Cancer Care Alliance, Mailstop G6-800, 825 Eastlake Ave. E Seattle, WA 98109, USA

Received 6 January 2010; Accepted 25 February 2010

Academic Editor: Werner Rabitsch

Copyright © 2010 Jennifer E. Vaughn and Ajay K. Gopal. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The finding of umbilical metastasis has historically been called a “Sister Mary Joseph Nodule”. A few case reports of lymphoma presenting in this manner have been documented. We report a case of relapsed mantle cell lymphoma (MCL) presenting as a Sister Mary Joseph's nodule. Although the few reports of lymphoma exhibiting umbilical metastasis suggest that patients may still expect a reasonable response to chemotherapy, this patient experienced multiple relapses, despite aggressive chemotherapy regimens. This clinical course is characteristic of the mantle cell form of non-hodgkin's lymphoma and illustrates a need to seek out more effective therapies.