Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2010, Article ID 782595, 4 pages
http://dx.doi.org/10.1155/2010/782595
Case Report

Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report

1Department of Internal Medicine, Hacettepe University Medical School, Sıhhiye, 06350 Ankara, Turkey
2Department of Endocrinology and Metabolism, Hacettepe University Medical School, 06350 Ankara, Turkey
3Department of Hematology, Hacettepe University Medical School, 06350 Ankara, Turkey
4Department of Dermatology, Hacettepe University Medical School, 06350 Ankara, Turkey

Received 29 August 2010; Accepted 6 December 2010

Academic Editor: Hermann E. Wasmuth

Copyright © 2010 Didem Ozdemir et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. P. Horny, K. Sotlar, and P. Valent, “Mastocytosis: state of the art,” Pathobiology, vol. 74, no. 2, pp. 121–132, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Tefferi and J. W. Vardiman, “Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms,” Leukemia, vol. 22, no. 1, pp. 14–22, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Akin and D. D. Metcalfe, “Systemic mastocytosis,” Annual Review of Medicine, vol. 55, pp. 419–432, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Golkar and J. D. Bernhard, “Mastocytosis,” The Lancet, vol. 349, no. 9062, pp. 1379–1385, 1997. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Marbello, M. Anghilieri, A. Nosari et al., “Aggressive systemic mastocytosis mimicking sclerosing cholangitis,” Haematologica, vol. 89, no. 9, p. ECR35, 2004. View at Google Scholar · View at Scopus
  6. R. S. Fishman, C. R. Fleming, and C. Y. Li, “Systemic mastocytosis with review of gastrointestinal manifestations,” Mayo Clinic Proceedings, vol. 54, no. 1, pp. 51–54, 1979. View at Google Scholar · View at Scopus
  7. P. Valent, C. Akin, L. Escribano et al., “Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria,” European Journal of Clinical Investigation, vol. 37, no. 6, pp. 435–453, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. K. H. Lim, A. Tefferi, T. L. Lasho et al., “Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors,” Blood, vol. 113, no. 23, pp. 5727–5736, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. H. C. Kluin-Nelemans, J. M. Oldhoff, J. J. van Doormaal et al., “Cladribine therapy for systemic mastocytosis,” Blood, vol. 102, no. 13, pp. 4270–4276, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Valent, C. Akin, W. R. Sperr et al., “Mastocytosis: pathology, genetics, and current options for therapy,” Leukemia and Lymphoma, vol. 46, no. 1, pp. 35–48, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. L. B. Schwartz, “Tryptase: a clinical indicator of mast cell-dependent events,” Allergy Proceedings, vol. 15, no. 3, pp. 119–123, 1994. View at Google Scholar · View at Scopus
  12. P. Valent, C. Akin, W. R. Sperr, H. P. Horny, and D. D. Metcalfe, “Mast cell proliferative disorders: current view on variants recognized by the World Health Organization,” Hematology/Oncology Clinics of North America, vol. 17, no. 5, pp. 1227–1241, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. J. H. Butterfield, A. Tefferi, and G. F. Kozuh, “Successful treatment of systemic mastocytosis with high-dose interferon-alfa: long-term follow-up of a case,” Leukemia Research, vol. 29, no. 2, pp. 131–134, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Casassus, N. Caillat-Vigneron, A. Martin et al., “Treatment of adult systemic mastocytosis with interferon-α: results of a multicentre phase II trial on 20 patients,” British Journal of Haematology, vol. 119, no. 4, pp. 1090–1097, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. B. Hennessy, F. Giles, J. Cortes et al., “Management of patients with systematic mastocytosis: review of M. D. Anderson Cancer Center experience,” American Journal of Hematology, vol. 77, no. 3, pp. 209–214, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Delaporte, E. Pierard, B. G. Wolthers et al., “Interferon-α in combination with corticosteroids improves systemic mast cell disease,” British Journal of Dermatology, vol. 132, no. 3, pp. 479–482, 1995. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Tefferi, C. Y. Li, J. H. Butterfield, and H. C. Hoagland, “Treatment of systemic mast-cell disease with cladribine,” The New England Journal of Medicine, vol. 344, no. 4, pp. 307–309, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. H. J. Droogendijk, H. J. C. Kluin-Nelemans, J. J. van Doormaal, A. P. Oranje, A. A. van de Loosdrecht, and P. L. A. van Daele, “Imatinib mesylate in the treatment of systemic mastocytosis: a phase II trial,” Cancer, vol. 107, no. 2, pp. 345–351, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Tefferi and A. Pardanani, “Systemic mastocytosis: current concepts and treatment advances,” Current Hematology Reports, vol. 3, no. 3, pp. 197–202, 2004. View at Google Scholar · View at Scopus
  20. A. Vega-Ruiz, J. E. Cortes, M. Sever et al., “Phase II study of imatinib mesylate as therapy for patients with systemic mastocytosis,” Leukemia Research, vol. 33, no. 11, pp. 1481–1484, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Kurosawa, H. Amano, N. Kanbe et al., “Response to cyclosporin and low-dose methylprednisolone in aggressive systemic mastocytosis,” Journal of Allergy and Clinical Immunology, vol. 103, no. 5, pp. S412–S420, 1999. View at Google Scholar · View at Scopus