Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2010, Article ID 986302, 3 pages
Case Report

Leigh's Disease: The Acute Clinical Course of a Two-Year-Old Child with Subacute Necrotizing Encephalomyelopathy

Institute of Legal Medicine, University of Munich, Nussbaumstraße 26, 80336 Munich, Germany

Received 4 January 2010; Accepted 7 April 2010

Academic Editor: Mamede de Carvalho

Copyright © 2010 Bettina Zinka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Leigh, “Subacute necrotizing encephalomyelopathie in an infant,” Journal of Neurology, Neurosurgery & Psychiatry, vol. 14, pp. 216–221, 1951. View at Google Scholar
  2. R. J. Huntsman, D. B. Sinclair, R. Bhargava, and A. Chan, “Atypical presentations of leigh syndrome: a case series and review,” Pediatric Neurology, vol. 32, no. 5, pp. 334–340, 2005. View at Publisher · View at Google Scholar · View at PubMed
  3. M. Spranger, S. Schwab, M. Wiebel, and C.-M. Becker, “Das adulte Leigh-syndrom,” Nervenarzt, vol. 66, no. 2, pp. 144–149, 1995. View at Google Scholar
  4. R. Tomczak, A. Rieber, H. Zeitler, and H.-J. Brambs, “Neugeborenes mit zerebraler symptomatik,” Radiologe, vol. 36, no. 7, pp. 591–592, 1996. View at Google Scholar
  5. S. Savasta, G. P. Comi, M. P. Perini et al., “Leigh disease: clinical, neuroradiologic, and biochemical study of three new cases with cytochrome c oxidase deficiency,” Journal of Child Neurology, vol. 16, no. 8, pp. 608–613, 2001. View at Google Scholar
  6. A. A. S. R. Mannan, M. C. Sharma, P. Shrivastava et al., “Leigh's syndrome,” Indian Journal of Pediatrics, vol. 71, no. 11, pp. 1029–1033, 2004. View at Google Scholar
  7. M. Crimi, A. Papadimitriou, S. Galbiati et al., “A new mitochondrial DNA mutation in ND3 gene causing severe Leigh syndrome with early lethality,” Pediatric Research, vol. 55, no. 5, pp. 842–846, 2004. View at Publisher · View at Google Scholar · View at PubMed
  8. M. Cacic, E. Wilichowski, V. Mejaski-Bosnjak et al., “Cytochrome c oxidase partial deficiency-associated leigh disease presenting as an extrapyramidal syndrome,” Journal of Child Neurology, vol. 16, no. 8, pp. 616–619, 2001. View at Google Scholar
  9. E. Pronicka, D. Piekutowska-Abramczuk, and M. Pronicki, “Metabolic diseases in children including Leigh syndrome—biochemical and molecular background,” Postepy Biochemii, vol. 54, no. 2, pp. 161–168, 2008. View at Google Scholar
  10. K. Naess, C. Freyer, H. Bruhn et al., “MtDNA mutations are a common cause of severe disease phenotypes in children with Leigh syndrome,” Biochimica et Biophysica Acta, vol. 1787, no. 5, pp. 484–490, 2009. View at Publisher · View at Google Scholar · View at PubMed