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Case Reports in Medicine
Volume 2011 (2011), Article ID 136396, 3 pages
http://dx.doi.org/10.1155/2011/136396
Case Report

Acute Management of Cocaine-Associated Methaemoglobinaemia

Acute Medicine Unit, Royal Alexandra Hospital, Corsebar Road, Paisley PA2 9PN, UK

Received 13 June 2011; Accepted 21 November 2011

Academic Editor: Jagdish Butany

Copyright © 2011 Immo Weichert. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. D. McKinney, K. F. Postiglione, and D. A. Herold, “Benzocaine-adultered street cocaine in association with methemoglobinemia,” Clinical Chemistry, vol. 38, no. 4, pp. 596–597, 1992. View at Google Scholar · View at Scopus
  2. UK Border Agency, “Further benzocaine seizure at Felixstowe,” 2010, http://www.ukba.homeoffice.gov.uk/sitecontent/newsarticles/2010/275292/25benzocain-felixstowe.
  3. I. Evrard, S. Legleye, and A. Cadet-Taïrou, “Composition, purity and perceived quality of street cocaine in France,” International Journal of Drug Policy, vol. 21, no. 5, pp. 399–406, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. E. J. Benz, “Disorders of hemoglobin,” in Harrison's Principles of Internal Medicine, A. S. Fauci, E. Braunwald, and D. L. Kasper, Eds., chapter 99, McGraw-Hill, New York, NY, USA, 17th edition, 2010. View at Google Scholar
  5. S. J. Barker, K. K. Tremper, and J. Hyatt, “Effects of methemoglobinemia on pulse oximetry and mixed venous oximetry,” Anesthesiology, vol. 70, no. 1, pp. 112–117, 1989. View at Google Scholar · View at Scopus
  6. S. T. Nguyen, R. E. Cabrales, C. A. Bashour et al., “Benzocaine-induced methemoglobinemia,” Anesthesia and Analgesia, vol. 90, no. 2, pp. 369–371, 2000. View at Google Scholar · View at Scopus
  7. E. Oechslin, “Hemoglobin cyanosis,” in Siegenthaler’s Differential Diagnosis in Internal Medicine, W. Siegenthaler, Ed., chapter 21.2, p. 709, Thieme, Stuttgart, Germany, 1st edition, 2005. View at Google Scholar
  8. I. Beckley, N. A. A. Ansari, H. A. Khwaja, and Y. Mohsen, “Clinical management of cocaine body packers: the Hillingdon experience,” Canadian Journal of Surgery, vol. 52, no. 5, pp. 417–421, 2009. View at Google Scholar · View at Scopus
  9. S. C. Curry, “Hematologic syndromes: hemolysis, methemoglobinemia, and sulfhemoglobinemia,” in Critical Care Toxicology, J. Brent, Ed., p. 339, Elsevier-Saunders, 2004. View at Google Scholar
  10. T. S. Do Nascimento, R. O. L. Pereira, H. L. D. De Mello, and J. Costa, “Methemoglobinemia: from diagnosis to treatment,” Revista Brasileira de Anestesiologia, vol. 58, no. 6, pp. 651–664, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Curry, “Methemoglobinemia,” Annals of Emergency Medicine, vol. 11, no. 4, pp. 214–221, 1982. View at Google Scholar · View at Scopus
  12. J. W. Harvey and A. S. Keitt, “Studies of the efficacy and potential hazards of methylene blue therapy in aniline-induced methaemoglobinaemia,” British Journal of Haematology, vol. 54, no. 1, pp. 29–41, 1983. View at Google Scholar · View at Scopus
  13. Daily Med Current Medication Information, National Library of Medicine, Methylene Blue, 2010, http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9ba51c5c-2bfe-44c7-92ab-87b54e4f89e6#nlm34090-1.
  14. K. Buchholz, R. H. Schirmer, J. K. Eubel et al., “Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum,” Antimicrobial Agents and Chemotherapy, vol. 52, no. 1, pp. 183–191, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. P. K. Gillman, “Methylene blue is a potent monoamine oxidase inhibitor,” Canadian Journal of Anesthesia, vol. 55, no. 5, pp. 311–312, 2008. View at Google Scholar · View at Scopus
  16. P. K. Gillman, “Methylene blue implicated in potentially fatal serotonin toxicity,” Anaesthesia, vol. 61, no. 10, pp. 1013–1014, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Z. Ables and R. Nagubilli, “Prevention, recognition, and management of serotonin syndrome,” American Family Physician, vol. 81, no. 9, pp. 1139–1142, 2010. View at Google Scholar · View at Scopus
  18. Medicines and Healthcare Products Regulatory Agency, Drug Safety Update, vol. 2, no. 9:3, 2009.
  19. T. Jansen, S. Barnung, C. R. Mortensen, and E. C. Jansen, “Isobutyl-nitrite-induced methemoglobinemia; treatment with an exchange blood transfusion during hyperbaric oxygenation,” Acta Anaesthesiologica Scandinavica, vol. 47, no. 10, pp. 1300–1301, 2003. View at Publisher · View at Google Scholar · View at Scopus