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Case Reports in Medicine
Volume 2011, Article ID 289389, 5 pages
Case Report

Detrusor Arreflexia as an End Stage of Neurogenic Bladder in HAM/TSP?

Serviço de Imunologia, Hospital Universitário Proffessor Edgard Santos, 5 Andar, Rua João das Botas S/N, Canela, Salvador CEP 40110-160, BA, Brazil

Received 19 October 2010; Accepted 22 February 2011

Academic Editor: Edgar M. Carvalho

Copyright © 2011 Matheus Tannus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The HTLV-1 virus is a known agent involved in the development of HAM/TSP. Past studies have typically observed patients with autonomic dysfunction consisting of detrusor overactivity and detrusor-sphincter dyssynergia, with the occasional observation of underactive detrusor or detrusor arreflexia. However, studies have not yet evaluated the progression of neurogenic bladder over time. In this paper, we describe a HAM/TSP patient with the initial development of overactive detrusor, and subsequent development of detrusor arreflexia. Given a paucity of studies characterizing the effects of HTLV-1 on the autonomic nervous system, particularly aspects controlling continence, this patient's clinical course may represent one type of end point for patients with HAM/TSP and neurogenic bladder. Further cohort or case-series studies, with particular emphasis on the progression of neurogenic bladder, are needed to evaluate the significance of this described case in relation to typical disease progression patterns.