Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency

Table 1

Laboratory results. *Maternal T cells in chimerism analysis. ^#Total chimerism 60% donor, 40% patient. Myeloid chimerism 100% patient, T and NK cell chimerism 100% donor.

Laboratory test	Patient prior to transplantation	Patient 3 months after transplantation	Patient 6 months after transplantation	Reference value
Serum immunoglobulins
IgA (mg/mL)	<0.1	0.12	0.15	0.2–0.6
IgG (mg/mL)	0,63	Substituted	Substituted	2.3–4.4
IgM (mg/mL)	0,351	0.79	0.32	0.3–0.9
Vaccine titers
Diphtheria (IU/mL)	0.25	Not done	Not done	>0.5
Tetanus (IU/mL)	0.13	Not done	Not done	>0.5
Isohemagglutinins	Undetected	Not done	Not done	>1/16
Lymphocyte subsets
CD3+ (cells/μL)	345*	124	1098	2300–6500
CD3+CD4+ (cells/μL)	8	69	960	1500–5000
CD3+CD4+CD45RA (%)	<1	62%	84%	64–92
CD3+CD8+ (cells/μL)	339*	13	91	500–1600
CD3+CD8+CD45RA (%)	0			53–88
CD19+ (cells/μL)	210	1062	3477	600–1300
CD56+ (cells/μL)	18	165	127	100–1000
Lymphocyte proliferation
Phytohemagglutinin (SI)	3	86
Anti-CD3 (SI)	1	24
PPD (SI)	1	9
Vβ TCR repertoire	restricted	Not done	Not done
Chimerism	75% maternal	100% donor	60% donor^#
Viral loads and PCR
CMV, EBV, HSV,	All negative	All negative	All negative
HIV1/2,HBV,HCV,
HHV6/7,VZV,
Enterovirus, Adenovirus
PCR Norovirus	Not done	+	+